CCL2

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, FC, IF, IHC
Protein Familie Lymphocyte Signaling
Menge 100ug
Host Rabbit
ArtNr A0313
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
11kDa
Immunogen
A synthetic peptide of human CCL2
Gene ID
6347
Swiss Prot
P13500
Synonyms
MCP-1; MCAF; HC11; SCYA2; MCP1; CCL2
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, monocyte chemotactic activating factor (MCAF) or glioma-derived chemotactic factor-2 (GDCF-2), is the product of the human JE gene and a member of the family of C-C (or ?) chemokines (1-4). The predicted molecular weight of MCP-1 protein is 11-13 kDa, but it may migrate at 20-30 kDa due to glycosylation. MCP-1 is secreted by a variety of cell types in response to pro-inflammatory stimuli and was originally described for its chemotactic activity on monocytes. This activity has led to studies demonstrating its role in diseases characterized by monocyte infiltrates such as psoriasis (5), rheumatoid arthritis (6) and atherosclerosis (7). MCP-1 may also contribute to tumor progression and angiogenesis (8). Signaling by MCP-1 is mediated by the G-protein coupled receptor CCR2 (9).
Recommended Dilutions
WB 1:200-1:500 IHC 1:50-1:100 IF 1:20-1:50 FC 1:20-1:50
illustration
Western blot analysis of HeLa cell lysate using CCL2 antibody.

Arbeitsanleitung

A0313.pdf

Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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