GSTP1

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, FC, IF, IHC
Protein Familie MAPK Signaling
Menge 100ug
Host Rabbit
ArtNr A0348
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
23kDa
Immunogen
A synthetic peptide of human GSTP1
Gene ID
2950
Swiss Prot
P09211
Synonyms
GSTP1; DFN7; FAEES3; GST3; PI ;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Glutathione S-transferases (GSTs) are a family of isoenzymes that detoxify electrophiles through conjugation to thiol-reduced glutathione (GSH). Thus, they are critical in protecting cells from toxins (drugs, pesticides, carcinogens) and oxidative stress (1). Eight isoforms of cytosolic-soluble GSTs (?, ?, ?, ?, ?, ?, ?, and ?) are identified, while only GST-?, -?, and -? are described in the central nervous system (2). GSTP1 (GST?) is overexpressed in early stages of carcinogenesis and can be used as a neoplastic marker in tumor tissues (3). GSTP1 directly inhibits TRAF2 and JNK but not NF-?B (4, 5). Corresponding GSTP1 gene polymorphisms affect substrate selectivity and stability, and the oxidative milieu in dopaminergic neurons, which increases the susceptibility to Parkinson’s disease (6).
Recommended Dilutions
WB 1:200-1:500 IHC 1:50-1:100 IF 1:10-1:50 FC 1:10-1:50
illustration
Western blot analysis of extracts of variouscell lines, using GSTP1 antibody.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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