Granzyme B

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, IF, IHC
Protein Familie Lymphocyte Signaling
Menge 100ug
Host Rabbit
ArtNr A0375
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
28kDa
Immunogen
Recombinant protein of human GZMB
Gene ID
3002
Swiss Prot
P10144
Synonyms
HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
GZMB(Granzyme B) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization(PMID:17283187).GzmB induces laminB degradation in isolated nuclei less ef?ciently than GzmA(PMID:11331782).This full length protein has 2 glycosylation sites and a signal peptide.Unglycosylated human granzyme B is 26 kDa and g high mannose glycosylated is 32 kDa and only 32kDa or smaller forms of granzyme B are accumulated within nuclei(PMID:8626751). This antibody is specific to GZMB
Recommended Dilutions
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100
illustration
Western blot analysis of extracts of HeLa cellline, using GZMB antibody.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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