Granzyme B

Hersteller	Abclonal
Typ	Antibody Polyclonal
Specific against	Human
Applikationen	WB, IF, IHC
Protein Familie	Lymphocyte Signaling
Menge	100ug
Host	Rabbit
ArtNr	A0375
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
*	DESCRIPTION
Calculated MW	28kDa
Immunogen	Recombinant protein of human GZMB
Gene ID	3002
Swiss Prot	P10144
Synonyms	HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	GZMB(Granzyme B) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization(PMID:17283187).GzmB induces laminB degradation in isolated nuclei less ef?ciently than GzmA(PMID:11331782).This full length protein has 2 glycosylation sites and a signal peptide.Unglycosylated human granzyme B is 26 kDa and g high mannose glycosylated is 32 kDa and only 32kDa or smaller forms of granzyme B are accumulated within nuclei(PMID:8626751). This antibody is specific to GZMB
Recommended Dilutions	WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100
illustration	Western blot analysis of extracts of HeLa cellline, using GZMB antibody.

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