IRE1alpha

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB
Protein Familie Protein Folding/Stability
Menge 100ug
Host Rabbit
ArtNr A0615
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Calculated MW
109kDa
Immunogen
A synthetic peptide of human ERN1
Synonyms
IRE1, Endoplasmicreticulum-to-nucleussignaling1, Inositol-requiring protein1, Ire1-alpha, Serine/threonine-protein kinase, Endoribonuclease
Purity
Affinity purification
Storage Buffer
Store at 4C or -20C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Illustration
Western blot analysis of extracts of ZR-75-1 cell line, using ERN1 antibody.
Gene Symbol
ERN1
GeneID (Human)
2081
GeneID
2081
Protein MW
977
SWISS
O75460
Route
Synthetic Peptide

Arbeitsanleitung

A0615.pdf

Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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Ihr Ansprechpartner:

Arne Pelz

sales@hoelzel.de