VE-Cadherin

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, FC
Protein Familie Angiogenesis
Menge 100ug
Host Rabbit
ArtNr A0734
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Calculated MW
88kDa
Immunogen
A synthetic peptide of human CDH5
Synonyms
CDH5, Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, CD_antigen=CD144, Flags: Precursor
Purity
Affinity purification
Storage Buffer
Store at 4C or -20C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development (1). The classic cadherin subfamily includes N-, P-, R-, B- and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with beta-catenin, gamma-catenin (also called plakoglobin), and p120 catenin. beta-catenin and gamma-catenin associate with alpha-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1, 2). While beta- and gamma-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking (1-4). E-cadherin is considered an active suppressor of invasion and growth of many epithelial cancers (1-3). Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion (3). In endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis (5, 6). Expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers (7, 8).
Illustration
Western blot analysis of extracts of 293 cellline, using CDH5antibody.
Gene Symbol
CDH5
GeneID (Human)
1003
GeneID
1003
Protein MW
784
SWISS
P33151
Route
Synthetic Peptide

Arbeitsanleitung

A0734.pdf

Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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