BGLAP

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, IHC
Menge 100ug
Host Rabbit
ArtNr A1530
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Calculated MW
11kDa
Immunogen
A synthetic peptide of human BGLAP
Synonyms
BGLAP, Osteocalcin, Bone Gla protein, Gamma-carboxyglutamicacid-containing protein
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Bone g-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis.
Illustration
Western blot analysis of extracts of 293cell line, using BGLAP antibody.
Gene Symbol
BGLAP
GeneID (Human)
632
GeneID
632
Protein MW
100
SWISS
P02818
Route
Synthetic Peptide
Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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