Axl

Hersteller Abclonal
Kategorie
Typ Antibody Monoclonal
Specific against Human
Applikationen WB, IF
Menge 100ug
Host Mouse
ArtNr A2480
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Calculated MW
97.4kDa
Immunogen
Recombinant protein of human AXL
Synonyms
UFO, JTK11
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Axl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-kappaB (2, 3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4).
Illustration
Western blot analysis of extracts of HepG2cell line, using AXL antibody.
Gene Symbol
AXL
GeneID (Human)
558
GeneID
558
Protein MW
894
SWISS
P30530
Route
Recombinant Protein
Menge: 100ug
Lieferbar: In stock
Listenpreis: 366,30 €
Preis: 366,30 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?
 
Schließen