Antibodies

UGT1A1

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Isotype IgG
Applikationen WB, IF, IHC
Menge 200ug
Host Rabbit
ArtNr A6186-200ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Gene Symbol
UGT1A1
Gene Template
Human
GeneID
54658
Route
Recombinant Protein
SWISS
P22309
Protein MW (aa)
60kDa
Synonyms
GNT1, UGT1, UDPGT, UGT1A, HUG-BR1, BILIQTL1, UDPGT 1-1,
Purity
Affinity purification
Storage Buffer
Store at -20C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Illustration
Western blot analysis of extracts of various cell lines, using UGT1A1 antibody.
Menge: 200ug
Lieferbar: In stock
Listenpreis: 404,00 €
Rabatt: -10,0%
Preis: 363,60 €
Sie sparen: 40,40 €
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Arbeitsanleitung

A6186-200ug.pdf