GCK

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse
Applikationen WB, IF, IHC
Protein Familie MAPK Signaling
Menge 100ug
Host Rabbit
ArtNr A0430
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Calculated MW
52kDa
Immunogen
A synthetic peptide of human GCK
Synonyms
GCK, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Germinal center kinase (GCK) is the founding member of the GCK family, a group of serine/threonine kinases homologous to the yeast Ste20 kinase. GCK is activated by TNF and associated with TRAF2 (TNF receptor-associated factor 2) and MEKK1, thereby activating the SAPK/JNK pathway (1, 2). GCK does not significantly phosphorylate MEKK1, instead it enhances MEKK1 oligomerization and autophosphorylation (3). GCK binds and activates MLK3, indicating that GCK may have other effectors (3).
Illustration
Western blot analysis of extracts of HepG2 celland livercell line, using GCK antibody.
Gene Symbol
GCK
GeneID (Human)
2645
GeneID
2645
Protein MW
465
SWISS
P35557
Route
Synthetic Peptide
Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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