BLNK

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse
Applikationen WB, IP
Protein Familie Lymphocyte Signaling
Menge 100ug
Host Rabbit
ArtNr A0638
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
50kDa
Immunogen
A synthetic peptide of human BLNK
Gene ID
29760
Swiss Prot
Q8WV28
Synonyms
bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
Recommended Dilutions
WB 1:500-1:1000 IHC 1:50-1:100 FC 1:20-1:50
illustration
Western blot analysis of extracts of NCI-H460celllines, using BLNK antibody.

Arbeitsanleitung

A0638.pdf

Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
lieferbar

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