B-Raf

Hersteller Abclonal
Kategorie
Typ Antibody Monoclonal
Specific against Human, Mouse
Applikationen WB, IHC, ICC
Menge 100ug
Host Mouse
ArtNr A2434
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Calculated MW
84kDa
Immunogen
Recombinant protein of human BRAF
Synonyms
BRAF1, RAFB1, B-RAF1, FLJ95109, NS7
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
BRAF: v-raf murine sarcoma viral oncogene homolog B1, also known as BRAF1, RAFB1, B-RAF1, FLJ95109. Entrez Protein NP_004324. It is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439). B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region, the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers. The BRAF gene mutation is frequently detected in papillary thyroid carcinoma, melanocytic nevi, primary cutaneous melanomas and colorectal cancers.
Illustration
Western blot analysis of extracts of various celllines, using BRAF antibody.
Gene Symbol
BRAF
GeneID (Human)
673
GeneID
673
Protein MW
766
SWISS
P15056
Route
Recombinant Protein
Menge: 100ug
Lieferbar: In stock
Listenpreis: 366,30 €
Preis: 366,30 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?
 
Schließen