Phospho-RAF1-S338

Hersteller Abclonal
Kategorie
Typ Antibody
Specific against Human, Mouse
Applikationen WB
Menge 50ug
Host Rabbit
ArtNr AP0208-50ug
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Calculated MW
73kDa
Immunogen
A phospho specific peptide corresponding to residues surrounding S338 of human RAF1
Synonyms
NS5, CRAF, Raf-1, c-Raf
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Gene Symbol
RAF1
GeneID (Human)
5894
GeneID
5894
Protein MW
648
SWISS
P04049
Route
Synthetic Peptide
Menge: 50ug
Lieferbar: In stock
Listenpreis: 246,40 €
Preis: 246,40 €
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