SHIP1

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB
Protein Familie Lymphocyte Signaling
Menge 200ug
Host Rabbit
ArtNr A0122-200ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Calculated MW
133kDa
Immunogen
A synthetic peptide of human INPP5D
Synonyms
SHIP, SHIP1, SHIP-1, hp51CN, SIP-145
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
INPP5D, also named as SHIP, SHIP1, SIP-145 and hp51CN, belongs to the inositol-1, 4, 5-trisphosphate 5-phosphatase family. INPP5D is phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) to produce PtdIns(3, 4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. INPP5D acts as a negative regulator of B-cell antigen receptor signaling. It mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. INPP5D acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. INPP5D regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. It is involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. It is a key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. It modulates FCGR3/CD16-mediated cytotoxicity in NK cells. It mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. INPP5D may also hydrolyze PtdIns(1, 3, 4, 5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
Illustration
Western blot analysis of extracts of Jurkatcell line, using INPP5D antibody.
Gene Symbol
INPP5D
GeneID (Human)
3635
GeneID
3635
Protein MW
1189
SWISS
Q92835
Route
Synthetic Peptide
Menge: 200ug
Lieferbar: In stock
Listenpreis: 540,10 €
Preis: 540,10 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?

Ihr Ansprechpartner:

Arne Pelz

sales@hoelzel.de

 
Schließen