Tuberin/TSC2

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB
Protein Familie Translational Control
Menge 50ug
Host Rabbit
ArtNr A0491-50ug
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
201kDa
Immunogen
A synthetic peptide of human TSC2
Gene ID
7249
Swiss Prot
P49815
Synonyms
LAM; TSC4;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
Recommended Dilutions
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:20-1:50
illustration
Western blot analysis of extracts of 293 cell line, using TSC2 antibody.
Menge: 50ug
Lieferbar: In stock
Listenpreis: 217,80 €
Preis: 217,80 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?
 
Schließen