Hamartin/TSC1

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB, IHC
Protein Familie AKT Signaling
Menge 50ug
Host Rabbit
ArtNr A0721-50ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Calculated MW
130kDa
Immunogen
A synthetic peptide of human TSC1
Synonyms
KIAA0243, LAM, MGC86987, TSC
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
TSC1, also named as KIAA0243 and TSC, is implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. In complex with TSC2, TSC1 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towards RHEB. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). The antibody is specific to TSC1.
Illustration
Western blot analysis of extracts of HeLa cellstissue, using TSC1antibody.
Gene Symbol
TSC1
GeneID (Human)
7248
GeneID
7248
Protein MW
1164
SWISS
Q92574
Route
Synthetic Peptide
Menge: 50ug
Lieferbar: In stock
Listenpreis: 270,60 €
Preis: 270,60 €
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