E-Cadherin

97kDa

999

CDH1; Arc-1; CD324; CDHE; ECAD; LCAM; UVO ; E-cadherin

Affinity purification

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]

Western blot analysis of extracts of Mouse testis using E-Cadherin antibody.Mouseanti-E-Cadherin (4A2C7) stained pancreas cancer. s cancer.