E-Cadherin

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB, IF, IHC
Menge 100ug
Host Rabbit
ArtNr A0965
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
97kDa
Immunogen
Fusion protein of human E-Cadherin
Gene ID
999
Swiss Prot
P12830
Synonyms
CDH1; Arc-1; CD324; CDHE; ECAD; LCAM; UVO ; E-cadherin
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Recommended Dilutions
WB 1:500-1:1000 IHC 1:50-1:100 IF 1:20-1:50
illustration
Western blot analysis of extracts of Mouse testis using E-Cadherin antibody.Mouseanti-E-Cadherin (4A2C7) stained pancreas cancer. s cancer.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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