F8

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB, IHC
Menge 200ug
Host Rabbit
ArtNr A1366-200ug
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Calculated MW
267kDa/25kDa
Immunogen
Recombinant protein of human F8
Synonyms
AHF, F8B, F8C, HEMA, FVIII, DXS1253E
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
Illustration
Western blot analysis of extracts of SW480 cellline, using F8 antibody.
Gene Symbol
F8
GeneID (Human)
2157
GeneID
2157
Protein MW
2351(216)
SWISS
P00451
Route
Recombinant protein
Menge: 200ug
Lieferbar: In stock
Listenpreis: 444,40 €
Preis: 444,40 €
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