CASR

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB
Menge 100ug
Host Rabbit
ArtNr A1426
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Calculated MW
121kDa
Immunogen
A synthetic peptide of human CASR
Synonyms
CAR, FHH, FIH, GPRC2A, HHC, HHC1, MGC138441, NSHPT, PCAR1
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
CASR, also named as GPRC2A, PCAR1, belongs to the G-protein coupled receptor 3 family. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. The activity of CASR is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciurichypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
Illustration
Western blot analysis of extracts of HL-60 cellslines, using CASR antibody.
Gene Symbol
CASR
GeneID (Human)
846
GeneID
846
Protein MW
707
SWISS
Q969H0
Route
Synthetic Peptide
Menge: 100ug
Lieferbar: In stock
lieferbar
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