BRD3

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB, IHC
Menge 100ug
Host Rabbit
ArtNr A2277
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
61kDa
Immunogen
Recombinant protein of human BRD3
Gene ID
8019
Swiss Prot
Q15059
Synonyms
FLJ23227; FLJ41328; KIAA0043; ORFX; RING3L;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Nuclear protein in testis (NUT) is normally confined to the germ cells of the testis and ovary (1, 2). NUT midline carcinoma (NMC) is a recently recognized cancer that is defined by the presence of chromosomal rearrangements involving the NUT gene on chromosome 15q14 (3). In most cases the chromosomal translocation occurs between NUT and BRD4 on chromosome 19, resulting in the formation of a BRD4-NUT fusion protein. In the remaining tumors, variant NUT rearrangements are present involving BRD3, a very close homolog of BRD4. BRD4-NUT and BRD3-NUT encode fusion proteins that appear to contribute to carcinogenesis by blocking epithelial cell differentiation. NMCs, which are aggressive and highly lethal carcinomas, are morphologically indistinguishable from other poorly differentiated carcinomas. Given the limited expression of endogenous NUT protein, this antibody can be used to detect NUT fusion proteins in tissues by immunohistochemistry and immunofluorescence (2).
Recommended Dilutions
WB 1:500-1:1000 IHC 1:50-1:100
illustration
Western blot analysis of extracts of various celllines, using AKT1 antibody.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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