SMAD4

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB, IHC
Menge 50ug
Host Rabbit
ArtNr A2642-50ug
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
61kD
Immunogen
Recombinant protein of human SMAD4
Gene ID
4089
Swiss Prot
Q13485
Synonyms
DPC4; JIP; MADH4;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Recommended Dilutions
WB 1:500-1:1000
illustration
Western blot analysis of extracts of various celllines, using SMAD4 antibody.
Menge: 50ug
Lieferbar: In stock
Listenpreis: 217,80 €
Preis: 217,80 €
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