Goat anti-DISC1 Antibody

Goat anti-DISC1 Antibody
Principle Name: DISC1
Official Symbol: DISC1
All Name and Symbols: DISC1; disrupted in schizophrenia 1 ; RP4-730B13.1; KIAA0457
Accession Number(s): NP_001012975.1; NP_061132.2
Peptide Sequence: HSEDKRKTPLKVLE, is from internal region
Human Gene ID(s): 27185
Non-Human GeneID(s):
Important Comments: This antibody is expected to recognise isoforms L ( NP_061132.2) and Lv (NP_001012975.1) only.
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied As: lyophilized powder of 50ug or 100ug IgG; Reconsititute IgG with 100ul or 200ul sterile DI Water and final product will be formulated as 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Aliquot and store at -20C. Minimize freezing and thawing.
Applications: Pep ELISA, WB
Tested Species: Human
Peptide ELISA: antibody detection limit dilution 1 to 128000.
Western Blot: Approx 100kDa band observed in Human Brain (Hippocampus) lysates (calculated MW of 93.6kDa according to NP_001012975.1). Recommended concentration: 0.1-0.3ug/ml.
Reference(s): Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ, Porteous DJ. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science. 2005 Nov 18; 310(5751):1187-91. .PMID: 16293762