InVivoMab anti-mouse 4-1BB (CD137) (Clone: LOB12.3)

Hersteller Bio X Cell
Kategorie
Typ Antibody Monoclonal
Specific against Mouse
Clon LOB12.3
Isotype IgG2a
Applikationen in vivo
Menge 50mg
Host Rat
ArtNr BE0169-50MG
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Quantity options
Description
The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- kappaB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growth in vivo when administered in combination with immune checkpoint inhibitors.
Endotoxin
<2EU/mg (<0.002EU/ug)
Determined by LAL gel clotting assay
Formulation
PBS, pH 8.0
Contains no stabilizers or preservatives
Immunogen
Mouse CD137 human Fc fusion protein
Isotype
Rat IgG1, kappa
Molecular Weight
150 kDa
Production
Purified from tissue culture supernatant in an animal free facility
Purification
Protein G
Purity
>95%
Determined by SDS-PAGE
RRID
AB_10949016
Recommended InVivoPure Dilution Buffer
InVivoPure pH 8.0 Dilution Buffer(IP0080)
Recommended Isotype Control(s)
InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase(BE0088)
Reported Applications
in vivo activation of 4-1BB
Sterility
0.2 uM filtered
Storage
The antibody solution should be stored at the stock concentration at 4C. Do not freeze.

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Menge: 50mg
Lieferbar: In stock
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