Antibodies

InVivoMab anti-mouse ICOS (Clone: 27A12)

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Hersteller Bio X Cell
Kategorie
Typ Antibody Monoclonal
Specific against Mouse
Clon 27A12
Isotype IgM
Applikationen in vivo
Menge 100mg
Host Hamster
ArtNr BE0226-100MG
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Quantity options
Produktname
InVivoMAb anti m ICOS (mICOS)
Produkt Info
Concentration is determined using an extinction coefficient equal to 1.33 Endotoxin level is determined using an LAL gel clotting test Purity determined by SDS-PAGE
Endotoxin
<2.0 EU/mg
Formulation
PBS, pH 7
Sterile
0.2 um filtration
Purity
>95%
Purification
T-Gel
Recommended Isotipe Control/Prduct
Polyclonal Hamster IgG
Recommended Isotipe Control/Catalog#
BE0091
Storage
Store at Room Temperature
Production
Tissue Culture
Isotype
Hamster IgM
Pathogen Test Result: Murine Pneumonia Virus
Negative
Pathogen Test Result: Mouse Hepatitis Virus
Negative
Pathogen Test Result: Mouse Minute Virus
Negative
Pathogen Test Result: Mouse Parvovirus
Negative
Pathogen Test Result: Sendai Virus
Negative
Pathogen Test Result: Murine Encephalomyelitis
Negative
Antigen
m ICOS
References
Dong, C., et al. (2001). "ICOS co-stimulatory receptor is essential for T-cell activation and function." Nature 409(6816): 97-101. PubMed

T-lymphocyte activation and immune function are regulated by co-stimulatory molecules. CD28, a receptor for B7 gene products, has a chief role in initiating T-cell immune responses. CTLA4, which binds B7 with a higher affinity, is induced after T-cell activation and is involved in downregulating T-cell responses. The inducible co-stimulatory molecule (ICOS), a third member of the CD28/CTLA4 family, is expressed on activated T cells. Its ligand B7H/B7RP-1 is expressed on B cells and in non-immune tissues after injection of lipopolysaccharide into animals. To understand the role of ICOS in T-cell activation and function, we generated and analysed ICOS-deficient mice. Here we show that T-cell activation and proliferation are defective in the absence of ICOS. In addition, ICOS -/- T cells fail to produce interleukin-4 when differentiated in vitro or when primed in vivo. ICOS is required for humoral immune responses after immunization with several antigens. ICOS-/- mice showed greatly enhanced susceptibility to experimental autoimmune encephalomyelitis, indicating that ICOS has a protective role in inflammatory autoimmune diseases.

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Menge: 100mg
Lieferbar: Out of stock
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