InVivoMab anti-human IFNgamma (Clone: B27)

Hersteller Bio X Cell
Kategorie
Typ Antibody Monoclonal
Specific against Human
Clon B27
Isotype IgG1
Applikationen in vivo
Menge 100mg
Host Mouse
ArtNr BE0245-100MG
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Quantity options
Description
The B27 monoclonal antibody reacts with human IFNgamma (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. IFNgamma is primarily produced by activated lymphocytes including T, B, NK cells, and ILCs. IFNgamma exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. Additionally, IFNgamma induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. IFNgamma has also been shown to modulate macrophage effector functions, influence isotype switching and induce the secretion of immunoglobulins by B cells. IFNgamma signals through the IFN gamma receptor which exists as a heterodimer composed of CD119 (IFN gamma receptor 1) and AF-1 (IFN gamma receptor 2). The IFNgamma receptor is expressed ubiquitously on almost all cell types with the exception of mature erythrocytes. The B27 antibody can neutralize the bioactivity of natural or recombinant IFNgamma.
Endotoxin
<2EU/mg (<0.002EU/ug)
Determined by LAL gel clotting assay
Formulation
PBS, pH 7.0
Contains no stabilizers or preservatives
Immunogen
Recombinant human IFNgamma
Isotype
Mouse IgG1
Molecular Weight
150 kDa
Production
Purified from tissue culture supernatant in an animal free facility
Purification
Protein G
Purity
>95%
Determined by SDS-PAGE
RRID
AB_2687726
Recommended InVivoPure Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer(IP0070)
Recommended Isotype Control(s)
InVivoMAb mouse IgG1 isotype control, unknown specificity(BE0083)
Reported Applications
Flow cytometry
Sterility
0.2 uM filtered
Storage
The antibody solution should be stored at the stock concentration at 4C. Do not freeze.

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Menge: 100mg
Lieferbar: In stock
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