InVivoMab anti-human EGFR (Clone: 225 (HB-8508))

Hersteller Bio X Cell
Kategorie
Typ Antibody Monoclonal
Specific against Human
Clon 225 (HB-8508)
Isotype IgG1
Applikationen in vivo
Menge 5mg
Host Mouse
ArtNr BE0278-5MG
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Quantity options
Description
The 225 monoclonal antibody reacts with an epitope on the extracellular domain of human EGFR belongs to the ErbB family of receptors. EGFR signaling is activated upon binding one of its ligands including epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), Amphiregulin, and heparin binding EGF (HB-EGF). Upon activation, EGFR transitions from an inactive monomeric form to an active homodimer. This initiates several downstream signal transduction cascades including the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. EGFR overexpression or constitutive activation are associated with many cancers. For this reason, anti-EGFR monoclonal antibody mediated immunotherapies are currently being explored as cancer treatments. The 225 antibody has been reported to neutralize EGFR signaling.
Endotoxin
<2EU/mg (<0.002EU/ug)
Determined by LAL gel clotting assay
Formulation
PBS, pH 7.0
Contains no stabilizers or preservatives
Immunogen
Purified EGFR from A431 cells
Isotype
Mouse IgG1
Molecular Weight
150 kDa
Production
Purified from tissue culture supernatant in an animal free facility
Purification
Protein G
Purity
>95%
Determined by SDS-PAGE
RRID
AB_2687801
Recommended InVivoPure Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer(IP0070)
Recommended Isotype Control(s)
InVivoMAb mouse IgG1 isotype control, unknown specificity(BE0083)
Reported Applications
in vitro EGFR blockade
in vivo EGFR blockade in xenografts
Western blot
Functional assays
Sterility
0.2 uM filtered
Storage
The antibody solution should be stored at the stock concentration at 4C. Do not freeze.

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Menge: 5mg
Lieferbar: In stock
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