Phospho-PTPN11 (Tyr580) Antibody

Polyclonal Antibody

PTPN11

BPTP3 antibody, CFC antibody, JMML antibody, METCDS antibody, MGC14433 antibody, NS1 antibody, OTTHUMP00000166107 antibody, OTTHUMP00000166108 antibody, Protein tyrosine phosphatase 2 antibody, Protein tyrosine phosphatase 2C antibody, Protein tyrosine phosphatase non receptor type 11 antibody, Protein-tyrosine phosphatase 1D antibody, Protein-tyrosine phosphatase 2C antibody, PTN11_HUMAN antibody, PTP-1D antibody, PTP-2C antibody, PTP1D antibody, PTP2C antibody, PTPN11 antibody, SAP2 antibody, SH-PTP2 antibody, SH-PTP3 antibody, SH2 domain containing protein tyrosine phosphatase 2 antibody, SHP 2 antibody, SHP-2 antibody, Shp2 antibody, SHPTP2 antibody, SHPTP3 antibody, Syp antibody, Tyrosine-protein phosphatase non-receptor type 11 antibody

Peptide sequence around phosphorylation site of tyrosine 580 (R-V-Y(p)-E-N) derived from Human SHP-2.

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

Ferjoux G, et al. (2003) Mol Biol Cell. 2003 , 14(9): 3911-3928.
Shi ZQ, et al. (2000) Mol Cell Biol , 20(5): 1526-1536.
Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A , 96(17): 9677-9682
Manes S, et al. (1999) Mol Cell Biol , 19(4): 3125-3135.
Oh ES, et al. (1999) Mol Cell Biol, 19(4): 3205-3215.
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Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Signal Transduction

Peptide sequence around phosphorylation site of tyrosine 580 (R-V-Y(p)-E-N) derived from Human SHP-2.