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Anti-Human Casp-5 (NT) - 0.1 mg

Anti-Human Casp-5 (NT) - 0.1 mg

ArtNr	LEIN-C1230-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Martinon, F. and Tschopp, J. (2004) Cell. 117(5):561-74. 2. Kuida, K. et al. (1995) Science. 267(5206):2000-3. 3. Gracie, JA. et al. (2003) J Leukoc Biol. 73(2):213-24. 4. Martinon, F. et al. (2002) Mol Cell. 10(2):417-26.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	Caspase-5
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.1 Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18.2, 3 Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1β.4
Background	Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.¹ Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18.^{2, 3} Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1β.⁴
PubMed	Caspase-5
Manufacturer - Specificity	Rabbit Anti-Human Casp-5 recognizes an epitope near the N-terminus of Human Casp-5. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2828374
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:C1272
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Caspase-5, ICH-3, ICE rel III , Casp-5, Human, Anti-Human Casp-5 (NT)

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LEIN-C1230-0.1mg-safety-datasheet.pdf