IKB ALPHA Antibody

ArtNr	OABB01774
Hersteller	AVIVA Systems Biology
Menge	100 ug/vial
Kategorie	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Adenocarcinoma Flow Cytometry Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, FC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ATG8F;Autophagy-related protein LC3 B;autophagy-related ubiquitin-like modifier LC3 B;LC3B;MAP1 light chain 3-like protein 2;MAP1A/1BLC3;MAP1A/MAP1B LC3 B;MAP1A/MAP1B light chain 3 B;MAP1LC3B-a;Microtubule-associated protein 1 light chain 3 beta;microtubule-associated proteins 1A/1B light chain 3B.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	MAP1LC3B
Gene Fullname	microtubule associated protein 1 light chain 3 beta
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	NFKBIA, also called IKBA or MAD-3, is one member of a family of cellular proteins that function to inhibit the NF-ICB transcription factor. It is mapped to 14q13.2. NFKBIA inhibits NF-ICB by masking the nuclear localization signals (NLS) of NF-ICB proteins and keeping them sequestered in an inactive state in the cytoplasm. It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. The effect of the nonpathogenic bacteria is specific to the SCF complex substrates CTNNB1 and NFKBIA. This may help to explain the beneficial effects of treatment of inflammatory bowel disease with nonpathogenic probiotic enteric organisms. In addition, NFKBIA blocks the ability of NF-ICB transcription factors to bind to DNA, which is required for NF-ICB's proper functioning.
Protein name	Microtubule-associated proteins 1A/1B light chain 3B
Clonality	Recombinant Monoclonal
Purification	Affinity Purified
Immunogen	A synthesized peptide derived from Human MAP1LC3B
Dilution	Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

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OABB01774-datasheet.pdf

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Menge: 100 ug/vial

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Lieferung vsl. bis 25.12.2025

Express-Lieferung: 1 Tage sparen

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