CD55 Antibody

ArtNr	OABB01970
Hersteller	AVIVA Systems Biology
Menge	100 ug/vial
Kategorie	Neuroscience Neuroinflammation Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IF, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CXXC3;CXXC-type zinc finger protein 3;methyl-CpG-binding domain protein 1;Methyl-CpG-binding protein MBD1;PCM1;protein containing methyl-CpG-binding domain 1;RFT;the regulator of fibroblast growth factor 2 (FGF-2) transcription.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	MBD1
Gene Fullname	methyl-CpG binding domain protein 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins.
Protein name	Methyl-CpG-binding domain protein 1
Clonality	Recombinant Monoclonal
Purification	Affinity Purified
Immunogen	A synthesized peptide derived from human MBD1
Dilution	Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

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OABB01970-datasheet.pdf

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Menge: 100 ug/vial

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Lieferung vsl. bis 25.12.2025

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