EYA2 Antibody

ArtNr	OACA02933
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neural Epigenetics Antibodies By Cell Type Carcinoma Melanoma Immunohistochemistry ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome." Patrick A.N., Cabrera J.H., Smith A.L., Chen X.S., Ford H.L., Zhao R.Nat. Struct. Mol. Biol. 20:447-453(2013) .
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	EAB1;eyes absent homolog 2.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	EYA2
Gene Fullname	EYA transcriptional coactivator and phosphatase 2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905).
Nucleotide accession_num	NM_005244
Protein accession_num	NP_005235
Protein name	Eyes absent homolog 2
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Eyes absent homolog 2 protein (1-514AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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Menge: 50 ug

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