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OPG Fc Protein (OPPA00531)

OPG Fc Protein (OPPA00531)

Hersteller	AVIVA Systems Biology
Kategorie	Neuroscience Neural Lineage Markers Metabolism Glucose Homeostasis Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	other
Format	OPG was lyophilized from a 0.2um filtered concentrated (0.5mg/ml) solution in PBS, pH= 7.4. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Menge	10ug
Host	Pichia Pastoris
ArtNr	OPPA00531
eClass 6.1	34160400
eClass 9.0	42020190
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Gene symbol	OPG Fc
Protein name	Tumor necrosis factor receptor superfamily member 11B
Product format	OPG was lyophilized from a 0.2um filtered concentrated solution in 20mM PB, pH 6.0, 150mM NaCl and 0.02 % Tween-80. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Gene id	4982
Reconstitution and storage	Reconstitution: It is recommended to reconstitute the lyophilized Osteoprotegerin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Storage: Lyophilized Osteoprotegerin although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution OCIF should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
Description of target	Osteoprotegerin acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. OPG inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local rankl/opg ratio. Osteoprotegerin may also play a role in preventing arterial calcification. May act as decoy receptor for trail and protect against apoptosis. Trail binding blocks the inhibition of osteoclastogenesis.
Purification	The OPG is purified by proprietary chromatographic techniques.
Biological activity	The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml, corresponding to a specific activity of >100, 000IU/mg in the presence of 10ng/ml soluble human RANKL (sRANKL).
Purity	Greater than 90.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

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Menge: 10ug

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Lieferung vsl. bis 30.05.2024

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