L-Asparaginase Protein (OPPA00809)

Hersteller AVIVA Systems Biology
Kategorie
Typ Proteins
Specific against other
Format The enzyme was lyophilized with no additives. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Menge 500U
Host E.coli
ArtNr OPPA00809
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene symbol
L-Asparaginase
Protein name
Isoaspartyl peptidase
Product format
Lyophilized. Sterile Filtered White (freeze-dried) powder with no additives.
Gene id
945456
Reconstitution and storage
It is recommended to reconstitute the lyophilized L-Asparaginase in 18MΩ -cm H2O at 1mg/ml. Lyophilized L-Asparaginase although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution L-Asparaginase should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles.
Description of target
L-Asparaginase is an enzyme that depletes L-Asparagine "an important nutrient for cancer cells" resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E.coli, which can inhibit the growth of malignant cells. It is used mainly for the induction of remission in acute lymphoblastic leukaemia. Because of the lymph node origin of malignant B cells in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and consequently, L-Asparaginase may be of value in managing the disease. The rationale behind asparaginase is that it takes advantage of the fact that ALL cellsare unable to synthesize the non-essential amino acidasparaginewhereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acidand ammonia. This deprives the leukemic cell of circulating asparagine.
Purification
L-Asparaginase was purified from E.coli ASI.357.
Biological activity
Unit Definition: One unit of enzyme catalyzes hadrylazation of 10 nanomoles of dUTP to dUMP in one hour at 85C
Activity: One IU of L- Asparaginase is defined as that amount of enzyme required to generate 1 μ mol of ammonia per minute at pH 7.3 and 37C.
Specific Activity: 225 IU/mg.
Purity
Greater than 96.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

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Menge: 500U
Lieferbar: In stock
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