HIF1A Protein (OPPA01377)

Kein Verkauf an Patienten, Ärzte, Apotheken oder Privatpersonen! Mehr erfahren

Wie zu jedem Jahresbeginn werden die Preise unserer Produkte aktualisiert. Bestellen Sie gerne trotzdem den gewünschten Artikel. Bei Preisabweichungen wird Sie unser Sales-Team binnen eines Werktages kontaktieren.

Aufgrund von Preisänderungen zum Jahreswechsel, kann es vorkommen, dass Preise teilweise noch nicht sichtbar sind. Stellen Sie gerne eine Angebotsanfrage. Vielen Dank für Ihr Verständnis.

Hersteller AVIVA Systems Biology
Kategorie
Typ Proteins
Specific against other
Format The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 and 1mM DTT. Physical appearance: Sterile filtered liquid formulation.
Menge 10ug
Host E.coli
ArtNr OPPA01377
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene symbol
HIF1A
Protein name
Hypoxia-inducible factor 1-alpha
Product format
Liquid. 20mM Tris-HCl pH-7.5 and 1mM DTT. Physical appearance: Sterile filtered liquid formulation.
Gene id
3091
Reconstitution and storage
Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time.   For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description of target
Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in cellular and systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1* subunit and one of three subunits (Hif-1*, Hif-2 (or Hif-3)). The activation of Hif-1 (is closely associated with a variety of tumors and oncogenic pathways. Hif-1 (consists of DNA binding domain (DBD domain), Dimerization domain and C-terminal regulatory domains, including two transactivation domains (TAD), an oxygen-dependent degradation (ODD) domain, and inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. It binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB and EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD and potentiates activation by NCOA1 and CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, and circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 and thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia.
Purification
Purified by proprietary chromatographic techniques.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Drywet
Wet Ice

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt und Sicherheitsdatenblatt) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Menge: 10ug
Lieferbar: In stock
lieferbar

Vergleichen

Auf den Wunschzettel

Lieferzeit anfragen

Technische Frage stellen

Bulk-Anfrage stellen

Fragen zum Produkt?
 
Schließen