InVivoPlus anti-mouse CTLA-4 (CD152)

Hersteller Bio X Cell
Kategorie
Typ Antibody Monoclonal
Specific against Mouse
Clon 9H10
Isotype IgG
Applikationen in vivo
Menge 25mg
Host Hamster
ArtNr BP0131-25MG
Eclass 6.1 32160702
Eclass 9.0 42030590
Lieferbar
Quantity options
Description
Aggregation determined by DLS
Concentration is determined using an extinction coefficient equal to 1.33
Endotoxin level is determined using an LAL gel clotting test
Purity determined by SDS-PAGE.
Function tested by Flow Cytometry
Endotoxin
< 1.0 EU/mg
Aggregation
< 5%
Formulation
PBS, pH 7
Sterile
0.2 µ m filtration
Purity
> 95%
Storage
Undiluted at 4C in the dark.
Reported Applications
ELISA Capture, Flow Cytometric Analysis
Production
Tissue culture
Purification
Protein G
Murine Pathogen Test Results
Mouse Norovirusurine Pneumonia Virus: Negative

Mouse Parvovirus: Negative

Mouse Minute Virus: Negative

Mouse Hepatitis Virus: Negative

Reovirus Screen: Negative

Lymphocytic Choriomeningitis virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Mouse Rotavirus: Negative

Theiler's Murine Encephalomyelitis: Negative

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

Polyoma Virus: Negative

Mouse Adenovirus: Negative

Sendai Virus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Mouse Cytomegalovirus: Negative

K Virus: Negative
References
1. Bartkowiak, T., et al. (2015). "Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine." Proc Natl Acad Sci U S A 112(38): E5290-5299.

2. Spranger, S., et al. (2015). "Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity." Nature 523(7559): 231-235.

3. Stephan, S. B., et al. (2015). "Biopolymer implants enhance the efficacy of adoptive T-cell therapy." Nat Biotechnol 33(1): 97-101.

4. Twyman-Saint Victor, C., et al. (2015). "Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer." Nature 520(7547): 373-377.

5. Krummey, S. M., et al. (2014). "Candida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockade." J Immunol 192(5): 2495-2504.

6. Ozdemir, B. C., et al. (2014). "Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival." Cancer Cell 25(6): 719-734.

7. Goding, S. R., et al. (2013). "Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma." J Immunol 190(9): 4899-4909.

8. Hervieu, A., et al. (2013). "Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth." J Invest Dermatol 133(2): 499-508.

9. Waitz, R., et al. (2012). "Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy." Cancer Res 72(2): 430-439.

10. Balachandran, V. P., et al. (2011). "Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido." Nat Med 17(9): 1094-1100.

11. Pedicord, V. A., et al. (2011). "Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance." Proc Natl Acad Sci U S A 108(1): 266-271.

12. Quezada, S. A., et al. (2010). "Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts." J Exp Med 207(3): 637-650.

Menge: 25mg
Lieferbar: In stock
Listenpreis: 2.061,40 €
Preis: 2.061,40 €
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