Antibodies

PTEN Polyclonal Antibody

Hersteller Biomatik
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen IHC, ELISA
Menge 100ug
Host Rabbit
ArtNr BM-CAC07126-100ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Immunogen
Recombinant human Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN protein (2-226AA)
Conjugate
Unconjugated
Alternative Names
Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1
UniProt ID
P60484
Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Instructions
Aliquot and store at -20C. Minimize freezing and thawing.
Expiry Date
1 year
Shipping Condition
Blue ice
Comment
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3, 4, 5)P3 > PtdIns(3, 4)P2 > PtdIns3P > Ins(1, 3, 4, 5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.
Restriction
For research use only. Not for diagnostic procedures.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 364,02 €
Preis: 364,02 €
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