Antibodies

DNMT3B Polyclonal Antibody

Hersteller Biomatik
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, IHC, ELISA
Menge 100ug
Host Rabbit
ArtNr BM-CAC07176-100ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Immunogen
Recombinant human DNA (cytosine-5)-methyltransferase 3B protein (1-100AA)
Conjugate
Unconjugated
Alternative Names
DNA (cytosine-5)-methyltransferase 3B, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB, DNMT3B
UniProt ID
Q9UBC3
Purification
Protein G purified, >95%
Storage Instructions
Aliquot and store at -20C. Minimize freezing and thawing.
Expiry Date
1 year
Shipping Condition
Blue ice
Comment
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
Restriction
For research use only. Not for diagnostic procedures.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 364,51 €
Preis: 364,51 €
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