|
Hersteller |
Biomatik |
|
Kategorie |
Produkte / Antibody / Research Area / Oncology / Bone Cancer |
|
Typ |
Antibody Polyclonal |
|
Specific against |
Human |
|
Menge |
50ug |
|
Host |
Rabbit |
|
ArtNr |
BM-CAC08581-50ug |
|
Eclass 6.1 |
32160702 |
|
Eclass 9.0 |
32160702 |
|
Lieferbar |
 |
| Clonality |
Polyclonal |
| Isotype info |
Recombinant Human NKG2-D type II integral membrane protein (73-216AA) |
| Immunogen |
ELISA, WB, IHC, IF; Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Conjugation |
Unconjugated |
| Alternative Names |
NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314, KLRK1, D12S2489E, NKG2D |
| UniProt ID |
P26718 |
| Purification |
>95%, Protein G purified |
| Storage |
-20°C |
| Expiry Date |
1 year |
| Shipping Condition |
Ice packs |
| Comments |
Conjugation service and the corresponding secondary antibody are available. |
| Technical Notes |
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
| Restriction |
For research use only. Not for diagnostic procedures. |
