Antibodies

PPP1CA Polyclonal Antibody

Hersteller Biomatik
Kategorie
Typ Antibody Polyclonal
Specific against Human
Menge 50ug
Host Rabbit
ArtNr BM-CAC08750-50ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Clonality
Polyclonal
Isotype info
Recombinant Human Serine/threonine-protein phosphatase PP1-alpha catalytic subunit protein (192-330AA)
Immunogen
ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
Conjugation
Unconjugated
Alternative Names
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PP-1A, PPP1CA, PPP1A
UniProt ID
P62136
Purification
>95%, Protein G purified
Storage
-20°C
Expiry Date
1 year
Shipping Condition
Ice packs
Comments
Conjugation service and the corresponding secondary antibody are available.
Technical Notes
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Restriction
For research use only. Not for diagnostic procedures.
Menge: 50ug
Lieferbar: In stock
Listenpreis: 216,57 €
Rabatt: -10,0%
Preis: 194,91 €
Sie sparen: 21,66 €
lieferbar

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