Antibodies

HIF1AN Polyclonal Antibody

Hersteller Biomatik
Kategorie Produkte / Antibody
Typ Antibody Polyclonal
Specific against Human, Mouse
Applikationen WB, IF, IP, IHC, ELISA
Menge 100ug
Host Rabbit
ArtNr BM-CAC07088-100ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Immunogen
Recombinant human Hypoxia-inducible factor 1-alpha inhibitor protein (2-254AA)
Conjugate
Unconjugated
Alternative Names
Hypoxia-inducible factor 1-alpha inhibitor (EC:1.14.11.30, EC:1.14.11.n4), HIF1AN, FIH1, Factor inhibiting HIF-1, FIH-1, Hypoxia-inducible factor asparagine hydroxylase
UniProt ID
Q9NWT6
Purification
Protein G purified, >95%
Storage Instructions
Aliquot and store at -20C. Minimize freezing and thawing.
Expiry Date
1 year
Shipping Condition
Blue ice
Comment
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Restriction
For research use only. Not for diagnostic procedures.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 333,35 €
Preis: 333,35 €
lieferbar

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