Hersteller |
Biomatik
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse |
Menge |
50ug |
Host |
Rabbit |
ArtNr |
BM-CAC08349-50ug |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Isotype info |
Recombinant Human Cytochrome P450 3A4 protein (259-441AA) |
Immunogen |
ELISA, WB, IHC, IF; Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Conjugation |
Unconjugated |
Alternative Names |
Cytochrome P450 3A4, 1, 8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cholesterol 25-hydroxylase, CYP3A4, CYP3A3 |
UniProt ID |
P08684 |
Purification |
>95%, Protein G purified |
Storage |
-20°C |
Expiry Date |
1 year |
Shipping Condition |
Ice packs |
Comments |
Conjugation service and the corresponding secondary antibody are available. |
Technical Notes |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1, 8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599). |
Restriction |
For research use only. Not for diagnostic procedures. |
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