Anti-APO-E Antibody

APO-E antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Polyclonal

APOE

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

APO-E Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Apolipoprotein E

Secreted

Occurs in all lipoprotein fractions in plasma.
It constitutes 10-20% of very low density lipoproteins (VLDL) and
1-2% of high density lipoproteins (HDL). APOE is produced in most
organs. Significant quantities are produced in liver, brain,
spleen, lung, adrenal, ovary, kidney and muscle.