Anti-HP Antibody (Center)

Primary Antibodies

45205 Da

IF: 1:10-1:50
WB: 1:1000-1:2000
IHC-P-Leica: 1:500
FC: 1:10-1:50

This gene encodes a preproprotein, which is processed to
yield both alpha and beta chains, which subsequently combine as a
tetramer to produce haptoglobin. Haptoglobin functions to bind free
plasma hemoglobin, which allows degradative enzymes to gain access
to the hemoglobin, while at the same time preventing loss of iron
through the kidneys and protecting the kidneys from damage by
hemoglobin. Mutations in this gene and/or its regulatory regions
cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also
been linked to diabetic nephropathy, the incidence of coronary
artery disease in type 1 diabetes, Crohn's disease, inflammatory
disease behavior, primary sclerosing cholangitis, susceptibility to
idiopathic Parkinson's disease, and a reduced incidence of
Plasmodium falciparum malaria. A similar duplicated gene is located
next to this gene on chromosome 16. Multiple transcript variants
encoding different isoforms have been found for this gene.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Cardiovascular, Cell Biology, Signal Transduction, Immunology

Secreted.

Expressed by the liver and secreted in plasma.