Anti-Ob-R LEPR Antibody

Primary Antibodies

132494 MW

WB: 1:500-1:1000
ICC/IF: 1:50-1:200

Leptin receptor

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Receptor for hormone LEP/leptin (Probable)
(PubMed:22405007). On ligand binding, mediates LEP central and
peripheral effects through the activation of different signaling
pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the
hypothalamus, LEP acts as an appetite-regulating factor that
induces a decrease in food intake and an increase in energy
consumption by inducing anorexinogenic factors and suppressing
orexigenic neuropeptides, also regulates bone mass and secretion
of hypothalamo-pituitary-adrenal hormones (By similarity)
(PubMed:9537324). In the periphery, increases basal metabolism,
influences reproductive function, regulates pancreatic beta-cell
function and insulin secretion, is pro-angiogenic and affects
innate and adaptive immunity (PubMed:25060689, PubMed:12504075,
PubMed:8805376). Control of energy homeostasis and melanocortin
production (stimulation of POMC and full repression of AgRP
transcription) is mediated by STAT3 signaling, whereas distinct
signals regulate NPY and the control of fertility, growth and
glucose homeostasis. Involved in the regulation of counter-
regulatory response to hypoglycemia by inhibiting neurons of the
parabrachial nucleus. Has a specific effect on T lymphocyte
responses, differentially regulating the proliferation of naive
and memory T -ells. Leptin increases Th1 and suppresses Th2
cytokine production (By similarity).

Boster Bio Anti-Ob-R LEPR Antibody catalog # A00350-3. Tested in WB, ICC/IF applications. This antibody reacts with Human, Rat.