Anti-FAP1 Antibody

Primary Antibodies

87713 MW

WB: 1:500-1:1, 000
IHC: 1:50-1:200

Prolyl endopeptidase FAP

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1.1 mg/mL by UV absorbance at 280 nm

Cell surface glycoprotein serine protease that
participates in extracellular matrix degradation and involved in
many cellular processes including tissue remodeling, fibrosis,
wound healing, inflammation and tumor growth. Both plasma membrane
and soluble forms exhibit post-proline cleaving endopeptidase
activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala
consensus sequences, on substrate such as alpha-2-antiplasmin
SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769,
PubMed:16480718, PubMed:16410248, PubMed:17381073,
PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also
gelatin, heat-denatured type I collagen, but not native collagen
type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin
or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219,
PubMed:10347120, PubMed:10455171, PubMed:12376466,
PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also
dipeptidyl peptidase activity, exhibiting the ability to hydrolyze
the prolyl bond two residues from the N-terminus of synthetic
dipeptide substrates provided that the penultimate residue is
proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro
and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601,
PubMed:16223769, PubMed:16651416, PubMed:16410248,
PubMed:17381073, PubMed:21314817, PubMed:24371721,
PubMed:24717288). Natural neuropeptide hormones for dipeptidyl
peptidase are the neuropeptide Y (NPY), peptide YY (PYY),
substance P (TAC1) and brain natriuretic peptide 32 (NPPB)
(PubMed:21314817). The plasma membrane form, in association with
either DPP4, PLAUR or integrins, is involved in the pericellular
proteolysis of the extracellular matrix (ECM), and hence promotes
cell adhesion, migration and invasion through the ECM. Plays a
role in tissue remodeling during development and wound healing.
Participates in the cell invasiveness towards the ECM in malignant
melanoma cancers. Enhances tumor growth progression by increasing
angiogenesis, collagen fiber degradation and apoptosis and by
reducing antitumor response of the immune system. Promotes glioma
cell invasion through the brain parenchyma by degrading the
proteoglycan brevican. Acts as a tumor suppressor in melanocytic
cells through regulation of cell proliferation and survival in a
serine protease activity-independent manner.

Boster Bio Anti-FAP1 Antibody catalog # A00422-3. Tested in WB, IHC applications. This antibody reacts with Human.