Anti-PDX1 Antibody

Primary Antibodies

30771 MW

IHC: 1:50-1:200
ICC/IF: 1:50-1:200
WB: 1:500

Pancreas/duodenum homeobox protein 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Activates insulin, somatostatin, glucokinase, islet
amyloid polypeptide and glucose transporter type 2 gene
transcription. Particularly involved in glucose-dependent
regulation of insulin gene transcription. As part of a
PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved
in the transcriptional activation of the ELA1 enhancer; the
complex binds to the enhancer B element and cooperates with the
transcription factor 1 complex (PTF1) bound to the enhancer A
element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'.
During development, specifies the early pancreatic epithelium,
permitting its proliferation, branching and subsequent
differentiation. At adult stage, required for maintaining the
hormone-producing phenotype of the beta-cell.

Boster Bio Anti-PDX1 Antibody catalog # A00491-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.