Anti-Clusterin-Alpha (E436) Antibody

Primary Antibodies

52495 MW

WB: 1:500-1:1000
IHC: 1:50-1:200
IF: 1:50-1:200

Clusterin

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Isoform 1 functions as extracellular chaperone that
prevents aggregation of nonnative proteins. Prevents stress-
induced aggregation of blood plasma proteins. Inhibits formation
of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and
aggregation-prone LYZ variants (in vitro). Does not require ATP.
Maintains partially unfolded proteins in a state appropriate for
subsequent refolding by other chaperones, such as HSPA8/HSC70.
Does not refold proteins by itself. Binding to cell surface
receptors triggers internalization of the chaperone-client complex
and subsequent lysosomal or proteasomal degradation. Secreted
isoform 1 protects cells against apoptosis and against cytolysis
by complement. Intracellular isoforms interact with ubiquitin and
SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase
complexes and promote the ubiquitination and subsequent
proteasomal degradation of target proteins. Promotes proteasomal
degradation of COMMD1 and IKBKB. Modulates NF-kappa-B
transcriptional activity. Nuclear isoforms promote apoptosis.
Mitochondrial isoforms suppress BAX-dependent release of
cytochrome c into the cytoplasm and inhibit apoptosis. Plays a
role in the regulation of cell proliferation.

Boster Bio Anti-Clusterin-Alpha (E436) Antibody catalog # A00590-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Apo-J, Complement cytolysis inhibitor, CLI, Complement-associated protein SP-40, 40, Ku70-binding protein 1, NA1/NA2, Testosterone-repressed prostate message 2, TRPM-2, Clusterin beta chain, ApoJalpha, Complement cytolysis inhibitor a chain, Clusterin alpha chain, ApoJbeta, Complement cytolysis inhibitor b chain, CLU, APOJ, CLI, KUB1, AAG4