Anti-SIRT6 Antibody

Primary Antibodies

39119 MW

WB: 1:1, 000
FC: 1:50-1:100
ICC: 1:50-1:200

NAD-dependent protein deacetylase sirtuin-6

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

NAD-dependent protein deacetylase. Has deacetylase
activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation
of histone H3 in telomeric chromatin during the S-phase of the
cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target
promoters and may down-regulate the expression of a subset of NF-
kappa-B target genes. Acts as a corepressor of the transcription
factor HIF1A to control the expression of multiple glycolytic
genes to regulate glucose homeostasis. Required for genomic
stability. Regulates the production of TNF protein. Has a role in
the regulation of life span (By similarity). Deacetylation of
nucleosomes interferes with RELA binding to target DNA. May be
required for the association of WRN with telomeres during S-phase
and for normal telomere maintenance. Required for genomic
stability. Required for normal IGF1 serum levels and normal
glucose homeostasis. Modulates cellular senescence and apoptosis.
On DNA damage, promotes DNA end resection via deacetylation of
RBBP8. Has very weak deacetylase activity and can bind NAD (+) in
the absence of acetylated substrate.

Boster Bio Anti-SIRT6 Antibody catalog # A00611-1. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.