Anti-OLR1 Antibody

Primary Antibodies

30959 MW

WB: 1:500-2000
IHC: 1:100-500
ICC: 1:100-500
IF: 1:100-500

Oxidized low-density lipoprotein receptor 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Receptor that mediates the recognition, internalization
and degradation of oxidatively modified low density lipoprotein
(oxLDL) by vascular endothelial cells. OxLDL is a marker of
atherosclerosis that induces vascular endothelial cell activation
and dysfunction, resulting in pro-inflammatory responses, pro-
oxidative conditions and apoptosis. Its association with oxLDL
induces the activation of NF-kappa-B through an increased
production of intracellular reactive oxygen and a variety of pro-
atherogenic cellular responses including a reduction of nitric
oxide (NO) release, monocyte adhesion and apoptosis. In addition
to binding oxLDL, it acts as a receptor for the HSP70 protein
involved in antigen cross-presentation to naive T-cells in
dendritic cells, thereby participating in cell-mediated antigen
cross-presentation. Also involved in inflammatory process, by
acting as a leukocyte-adhesion molecule at the vascular interface
in endotoxin-induced inflammation. Also acts as a receptor for
advanced glycation end (AGE) products, activated platelets,
monocytes, apoptotic cells and both Gram-negative and Gram-
positive bacteria.

Boster Bio Anti-OLR1 Antibody catalog # A00760-4. Tested in WB, IHC, ICC, IF applications. This antibody reacts with Human, Rat.

Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, C-type lectin domain family 8 member A, Lectin-like oxidized LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1, Lectin-type oxidized LDL receptor 1, Oxidized low-density lipoprotein receptor 1, soluble form, OLR1, CLEC8A, LOX1