Anti-CHOP Monoclonal Antibody

Hersteller Boster
Kategorie
Typ Antibody Monoclonal
Specific against other
Applikationen WB, IHC
Menge 100ul
Host Mouse
ArtNr BOS-A00311-1
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Gene name
DDIT3
Clonality
Monoclonal
Clone number
2B1
Conjugate
No
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Description
Monoclonal clone# G2 antibody for CHOP/DDIT3 detection. Host: Mouse.Size: 100ul. Tested applications: IHC. Reactive species: Human. CHOP/DDIT3 information: Molecular Weight: 19175 MW; Subcellular Localization: Cytoplasm. Nucleus. Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Uniprot ID
P35638
Immunogen
Synthetic Peptide of CHOP
Purification
Protein A purified
Storage
Store at -20° C for one year, at 4° C for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20° C upon receiving. Avoid repeated freezing and thawing.
Application details
WB, 1:1000-2000
IHC, 1:100-200
Reactivity
Human, Mouse, Rat
Research category
|epigenetics and nuclear signaling|transcription|other factors| stem cells|embryonic stem cells|intracellular| developmental biology|embryogenesis|surface molecules| metabolism|types of disease|diabetes|obesity|metabolic disorders
Synonyms
DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, DDIT3, CHOP, CHOP10, GADD153,
Molecular weight
19175 MW
Protein function
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. .

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Menge: 100ul
Lieferbar: Out of stock
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