Anti-MLL Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen IHC
Menge 100ul
Host Rabbit
ArtNr BOS-A00402
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
KMT2A
Clonality
Polyclonal
Conjugate
No
Contents
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Description
Polyclonal antibody for MLL/KMT2A detection. Host: Rabbit.Size: 100ul. Tested applications: IHC. Reactive species: Human. MLL/KMT2A information: Molecular Weight: 431764 MW; Subcellular Localization: Nucleus ; Tissue Specificity: Heart, lung, brain and T- and B-lymphocytes.
Uniprot ID
Q03164
Immunogen
Synthetic peptide from human protein at AA range: 3850-3900.
Purification
Immunogen affinity purified
Storage
Store at -20° C for one year, at 4° C for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20° C upon receiving. Avoid repeated freezing and thawing.
Application details
IHC-P, 1:50-300
Reactivity
Human, Mouse, Rat
Research category
|epigenetics and nuclear signaling|transcription|other factors| epigenetics and nuclear signaling|chromatin remodeling|trithorax| cancer|oncoproteins/suppressors|oncoproteins
Synonyms
Histone-lysine N-methyltransferase 2A, Lysine N-methyltransferase 2A, 2.1.1.43, ALL-1, CXXC-type zinc finger protein 7, Myeloid/lymphoid or mixed-lineage leukemia, Myeloid/lymphoid or mixed-lineage leukemia protein 1, Trithorax-like protein, Zinc finger protein HRX, MLL cleavage product N320, N-terminal cleavage product of 320 kDa, p320, MLL cleavage product C180, C-terminal cleavage product of 180 kDa, p180, KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1,
Molecular weight
431764 MW
Protein function
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). .

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Menge: 100ul
Lieferbar: Out of stock
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